p53:MYB:SIN3A p53, SIN3A and MYB form a complex Authored: Akkerman, JW, 2010-10-29 Edited: Jupe, S, 2010-11-12 Pubmed10378697 Pubmed14761981 Pubmed15509555 Pubmed16597594 Pubmed1709592 Pubmed19252138 Pubmed20599537 Pubmed2413449 Pubmed8710361 Reactome Database ID Release 43992696 Reactome, http://www.reactome.org ReactomeREACT_25138 Reviewed: Ouwehand, WH, 2010-11-12 The DNA-binding domain of c-Myb binds the co-repressor protein SIN3A (Nomura et al. 2004). The tumor repressor p53 also binds MYB directly (Tanikawa et al. 2004), promoting formation of a trimeric SIN3A:c-Myb:p53 complex. This does not affect the ability of c-Myb to bind to DNA, but may represent the mechanism that allows p53 to to regulate specific Myb target genes. <br>c-Myb (gene symbol MYB) is highly conserved in all vertebrates and some invertebrate species (Lipsick 1996). It plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells (Duprey & Boettiger 1985); Down-regulation of c-Myb is believed to be critical for the commitment of cells to terminal differentiation (Oh & Reddy, 1999). c-Myb interacts with many other transcription factors including CBP, several CCAAT binding protein (c/EBP) family members, and Ets family proteins such as Ets-2 (Oh & Reddy, 1999). <br>Loss of c-Myb function results in embryonic lethality due to failure of fetal hepatic hematopoiesis (Mucenski et al. 1991).