Integrin alphaVbeta3 Integrin alphaVbeta3:PECAM-1 Interaction of integrin alphaVbeta3 with PECAM-1 Alpha v beta 3 integrin is one of the potential heterophilic ligands of PECAM-1 that is involved in down-regulation of T-cell responses. The heterophilic interaction of alpha v beta 3 integrin on endothelial cells with PEACAM-1 on leukocytes increases the adhesive function of beta integrins on T cells, monocytes, neutrophils and NK cells suggesting that leukocyte PEACAM-1 act as a signaling molecule. Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 Pubmed7542249 Pubmed8838667 Reactome Database ID Release 43210304 Reactome, http://www.reactome.org ReactomeREACT_12468 Reviewed: Trowsdale, J, 2008-02-26 12:02:59