PECAM-1:PECAM-1 p-PECAM1:p-PECAM1 Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 EC Number: 2.7.10 PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules. Pubmed10858437 Pubmed9624175 Reactome Database ID Release 43210291 Reactome, http://www.reactome.org ReactomeREACT_12408 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 has a Stoichiometric coefficient of 4