PECAM-1:SHIP1 complex Interaction of PECAM-1 and SHIP Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 PECAM/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activation and angiogenesis. It has six Ig homology domains within its extracellularly and an ITIM motif within its cytoplasmic region. <br>PECAM-mediated adhesion is complex, because it is capable of binding both to itself (homophilic adhesion) and to non-PECAM ligands (heterophilic adhesion). The trans-homophilic interaction between the two PECAM-1 molecules is mediated by their NH2-terminal membrane distal Ig homology domains 1 and 2 plus the proper spacing formed by the six Ig-homology domains. Pubmed10350061 Reactome Database ID Release 43210290 Reactome, http://www.reactome.org ReactomeREACT_12476 Reviewed: Trowsdale, J, 2008-02-26 12:02:59