CyP60 complexed with Basigin CyP60 chaperones Basigin Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 Basigin serves as a signaling receptor for extracellular cyclophilins. Its been reported that cyclophilin 60 (Cyp60), a distinct member of the cyclophilin family is involved in the regulation of intracellular transport of basigin. The mechanism of this activity involves interaction of Cyp60 with the proline-containing region within or adjacent to the predicted transmembrane domain basigin. Cyp60 is co-localized with basigin at the plasma membrane suggesting that Cyp60 may function as a chaperone escorting basigin through the secretory pathway. Pubmed15946952 Reactome Database ID Release 43204500 Reactome, http://www.reactome.org ReactomeREACT_12550 Reviewed: Trowsdale, J, 2008-02-26 12:02:59