Basigin:MMP1 Basigin binds Matrix metalloproteinase-1 Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 Basigin expressed on the surface of most tumor cells, stimulates stromal cells to produce elevated levels of several matrix metalloproteinases (MMP), including interstitial collagenase (MMP-1). MMPs have been implicated in several aspects of tumor progression, including invasion through basement membranes and interstitial matrices, angiogenesis, and tumor cell growth. Basigin not only stimulates the production of MMP-1 but also forms a complex with MMP-1 at the tumor cell surface and this interaction may be important in modifying the tumor cell pericellular matrix to promote invasion. Edited: Garapati, P V, 2009-03-16 17:55:42 Pubmed10706100 Reactome Database ID Release 43375135 Reactome, http://www.reactome.org ReactomeREACT_16941 Reviewed: Trowsdale, J, 2008-02-26 12:02:59