Kinesin-1 Kinesin-1 light chains Kinesin-1 heavy chain Kinesin-1 is a heterotetramer Authored: Akkerman, JW, 2010-10-29 Edited: Jupe, S, 2010-11-15 Kinesin-1 is a heterotetramer of two heavy chains (HCs) and two light chains (LCs). The HC tail binds microtubules and inhibits ATPase activity by interacting with the enzymatic HC heads. LCs regulate the head and microtubule-binding activities of the HC tail by reducing the affinity of the head-tail interaction over tenfold. By a separate mechanism LCs inhibit microtubule binding. Pubmed1607388 Pubmed20547877 Pubmed3130248 Pubmed3134048 Reactome Database ID Release 43983194 Reactome, http://www.reactome.org ReactomeREACT_25083 Reviewed: Ouwehand, WH, 2010-11-12 has a Stoichiometric coefficient of 2