CP LRRC16A:F-actin capping protein LRRC16A binds F-actin capping protein Authored: Akkerman, JW, 2010-10-29 Edited: Jupe, S, 2010-11-12 Leucine rich repeat-containing protein 16A (CARMIL homolog) binds F-actin capping protein (CP) with high affinity, significantly decreasing the affinity of CP for actin barbed ends. Actin polymerization occurs at the barbed end; proteins like CP that cap the barbed end inhibit elongation. Inhibition of CP therefore enhances the rate of barbed-end actin polymerization. In cells, GFP-LRRC16A was seen to be concentrated in lamellipodia and increased the fraction of cells with large lamellipodia. Decreasing LRRC16A levels with siRNA lowered F-actin levels, decreased lamellipodia protrusion and slowed cell migration. Pubmed16054028 Pubmed20625546 Reactome Database ID Release 43994148 Reactome, http://www.reactome.org ReactomeREACT_25319 Reviewed: Ouwehand, WH, 2010-11-12