CENP-E dimer Kinesin-7 is a dimer Authored: Akkerman, JW, 2010-10-29 Edited: Jupe, S, 2010-11-15 Human kinesin-7, or CENP-E was one of the first kinesins to be discovered (Yen et al. 1991). It is essential for mammalian development, having a role in stabilizing kinetochore-microtubule capture (Putkey et al. 2002), CENP-E is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules and localizes to kinetochores throughout all phases of mitotic chromosome movement (early premetaphase through anaphase A). Though originally reported to be minus-end-directed it is now believed to be a plus-end-directed dimeric kinesin (Espeut et al. 2008). It is sequestered in the cytoplasm until nuclear envelope breakdown and then localizes to its chromosomal cargo at the kinetochores (Brown et al. 1996). Pubmed12361599 Pubmed18342609 Pubmed2022189 Pubmed8743943 Reactome Database ID Release 43984689 Reactome, http://www.reactome.org ReactomeREACT_25390 Reviewed: Ouwehand, WH, 2010-11-12 has a Stoichiometric coefficient of 2