G-protein beta-gamma complex G-protein alpha (q/11): GTP Ligands of GPCRs that activate Gq/11 GPCRs that activate Gq/11 Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) The Ligand:GPCR:Gq complex dissociates Authored: Jupe, S, 2010-05-18 Edited: Jupe, S, 2010-05-26 Pubmed18577758 Pubmed8736705 Reactome Database ID Release 43749452 Reactome, http://www.reactome.org ReactomeREACT_22263 Reviewed: D'Eustachio, P, 2010-05-21 The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (q) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).