PI3K alpha G-protein alpha (q/11): GTP G-protein alpha (q/11):PI3K alpha G alpha (q) inhibits PI3K alpha Authored: Jupe, S, 2009-03-26 17:21:12 Edited: Jupe, S, 2009-09-09 Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778). Pubmed16268778 Pubmed18515384 Reactome Database ID Release 43416358 Reactome, http://www.reactome.org ReactomeREACT_19172 Reviewed: Akkerman, JW, 2009-06-03