G-protein alpha (q/11): GTP G-protein alpha (q):GRK2 GRK2 sequesters activated Gq Authored: Jupe, S, 2009-03-27 16:14:26 Edited: Jupe, S, 2009-09-09 GRK2 can inhibit GPCR signaling via phosphorylation-independent sequestration of Gq/11/14 subunits utilising its RGS homology (RH) domain. GRK2 may be an effector of activated Gq, initiating signalling cascades other than the classical PLC beta signalling associated with Gq. Pubmed10567430 Pubmed16339447 Pubmed18936096 Reactome Database ID Release 43416516 Reactome, http://www.reactome.org ReactomeREACT_19213 Reviewed: Akkerman, JW, 2009-06-03