G-protein alpha (q/11): GTP G-protein alpha (q):GRK5 GRK5 sequesters activated Gq Authored: Jupe, S, 2009-03-27 16:14:26 Edited: Jupe, S, 2009-09-09 GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells. Pubmed10861009 Reactome Database ID Release 43416510 Reactome, http://www.reactome.org ReactomeREACT_19325 Reviewed: Akkerman, JW, 2009-06-03