G-protein G12/G13 (inactive) Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). Ligand:GPCR complexes that activate G12/13 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 About 25 receptors are reported to couple to the G12/13 G protein subtype (Riobo & Manning, 2005).Direct assay methods have not identified a receptor that only couples with G12. At least one receptor (5-HT4) only couples with G13, but most other receptors are reported to couple with both G12 and G13. Authored: Jupe, S, 2010-05-18 Edited: Jupe, S, 2010-05-26 Pubmed12433842 Pubmed15749160 Pubmed18374420 Reactome Database ID Release 43751027 Reactome, http://www.reactome.org ReactomeREACT_22424 Reviewed: D'Eustachio, P, 2010-05-21