Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). Liganded G12/13-activating GPCR acts as a GEF for G12/13 Authored: Jupe, S, 2009-02-26 15:51:29 Edited: Jupe, S, 2010-05-26 Pubmed19212140 Pubmed3086311 Pubmed3113327 Pubmed9032437 Reactome Database ID Release 43751029 Reactome, http://www.reactome.org ReactomeREACT_22370 Reviewed: D'Eustachio, P, 2010-05-21 The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.