ROCK RhoA/B/C:GTP Activated ROCK:RhoA/B/C:GTP ROCK activation by Rho Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2009-05-20 09:50:28 Pubmed12778124 Pubmed8617235 Pubmed9920927 Reactome Database ID Release 43419049 Reactome, http://www.reactome.org ReactomeREACT_19389 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01 Rho-associated, coiled-coil containing protein kinases (ROCKs) are primarily known as downstream effectors of Rho, but they can also be activated by arachidonic acid, which binds to the pleckstrin homology domain, releasing an autoinhibitory loop within ROCK allowing catalytic activity. Multiple targets of ROCK contribute to the stabilization of actin filaments and the generation of actin-myosin contractile force.