G-protein alpha (12/13):GTP G-protein alpha (12/13):LARG LARG activation by G alpha 12/13 Authored: Jupe, S, 2009-03-18 10:07:56 Edited: Jupe, S, 2009-09-09 Leukemia-associated RhoGEF (LARG) serves as a G alpha responsive RhoGEF for G alpha 12, 13 and possibly G alpha q. G alpha 12 activity appears to depend on LARG tyrosine phosphorylation by Tec-family kinases (Suzuki et al. 2003) or FAK (Chikumi et al. 2002). The involvement of LARG may be specific to particular receptor signalling pathways; RNAi-mediated knockdown of LARG specifically inhibited thrombin signaling via PAR1 but not LPA receptors (Wang et al 2004). Pubmed11799111 Pubmed12515866 Pubmed12771155 Pubmed15143072 Pubmed15951850 Reactome Database ID Release 43398184 Reactome, http://www.reactome.org ReactomeREACT_19158 Reviewed: Akkerman, JW, 2009-06-03