Opioid:MOR:G protein-GDP complex Opioid:MOR G protein-GDP complex The high affinity receptor complex binds to G-protein Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed10215864 Pubmed11786497 Pubmed16415903 Pubmed9544801 Reactome Database ID Release 43167408 Reactome, http://www.reactome.org ReactomeREACT_15298 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 The high affinity complex beta-endorphin:mu opioid receptor binds to the heterotrimeric G-protein. This binding stabilises a conformation of the G-protein alpha i subunit presenting a low affinity for GDP, but a high affinity for GTP