Opioid peptide Opioid:MOR Opioid dissociates from MOR Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Different ligands of the MOR receptor can promote MOR phosphorylation, uncoupling, endocytosis or inactivation. For example, the endogenous peptide ligands at the MOR induce rapid desensitization, endocytosis and rapid receptor recycling. By contrast, morphine induces little to no endocytosis, tolerance and dependence. The agonist-dependent phosphorylation of opioid receptors changes the receptor conformation and increases the affinity of the receptors for cytosolic beta-arrestin proteins. This results in an uncoupling of G protein signalling and recruitment of the endocytotic machinery leading to receptor internalization and rapid resensitization. By contrast, PKC phosphorylation by non internalizing opioid ligands (e.g., morphine) cause receptors to remain inactivated in the plasma membrane, leading to signaling desensitization and opioid tolerance. In this case receptors appear to require activity of a phosphatase to be resensitized. Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed15272312 Pubmed16682505 Reactome Database ID Release 43167427 Reactome, http://www.reactome.org ReactomeREACT_15388 Reviewed: Castagnoli, L, 2008-11-06 12:55:54