PIP2 hydrolysis Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 EC Number: 3.1.4.11 Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed11118617 Reactome Database ID Release 43111879 Reactome, http://www.reactome.org ReactomeREACT_15353 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. One type, PLC-beta1, hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.