CGRP ligands CGRP receptor can bind calcitonin gene-related peptides Authored: Jassal, B, 2009-05-11 13:30:54 Edited: Jassal, B, 2009-05-11 13:30:54 Pubmed14722252 Pubmed2177866 Pubmed2985435 Pubmed6609312 Pubmed8626685 Reactome Database ID Release 43420127 Reactome, http://www.reactome.org ReactomeREACT_18360 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 The calcitonin gene-related peptides alpha-CGRP and beta-CGRP (Morris HR et al, 1984, Steenbergh PH et al, 1985 respectively) are members of the calcitonin family of peptides and are produced in both peripheral and central neurons. They are the most potent peptide vasodilators and can function in the transmission of pain. Their effects are mediated by binding to the CGRP1 receptor (CL) (Aiyar N et al, 1996). CGRP receptors are complexes between CL and receptor activity modifying protein 1 (RAMP1) (Kuwasako K et al, 2004). The activity of the receptor is mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Van Valen et al, 1990). CGRP1 receptor:CGRP CGRP receptor