Parathyroid hormone receptors Parathyroid hormone-type ligands Parathyroid hormone receptor can bind parathyroid hormone Authored: Jassal, B, 2009-05-12 14:18:01 Edited: Jassal, B, 2009-05-12 14:18:01 Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroid hormone-related protein (PTHrP) (Suva LJ et al, 1987) and tuberoinfundibular peptide of thirty-nine residues (TIP39) (Hansen IA et al, 2002; Della Penna K et al, 2003) are endogenous ligands for the parathyroid hormone 1 and 2 receptors. These peptide hormones play a key role in controlling blood Ca(2+) concentration and endochondral bone formation. PTH1 is the classical PTH receptor 1 (Schipani E et al, 1993; Schneider H et al, 1993) and is expressed in high levels in bone and kidney. It regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. PTH receptor 2 (Usdin TB et al, 1995) is most abundant in brain and testes and potently activated by PTH. The activity of these receptors is mediated by G proteins which activate adenylyl cyclase (Schneider H et al, 1994; Offermanns S et al, 1996; Behar V et al, 1996). Pubmed12098667 Pubmed12559132 Pubmed3616618 Pubmed6950381 Pubmed7797535 Pubmed8082781 Pubmed8386612 Pubmed8397094 Pubmed8732687 Pubmed8770894 Reactome Database ID Release 43420489 Reactome, http://www.reactome.org ReactomeREACT_18314 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 Parathyroid hormone receptors:parathyroid hormone-type ligands