PACAP peptides The PACAP receptor binds PACAP Authored: Jassal, B, 2009-05-11 13:30:54 Edited: Jassal, B, 2009-05-11 13:30:54 Pubmed1739432 Pubmed7902709 Reactome Database ID Release 43420131 Reactome, http://www.reactome.org ReactomeREACT_18424 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 The pituitary adenylate cyclase-activating peptide (PACAP) (Ohkubo S et al, 1992) is a peptide hormone similar to vasoactive intestinal peptide (VIP). PACAP functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator. Three active peptides are cleaved from the precursor protein; PACAP-related peptide, PACAP-27 and PACAP-38. The effects of the PACAP peptides are mediated by the PACAP receptor (Ogi K et al, 1993). This receptor is predominantly expressed in the CNS. The activity of the receptor is mediated by coupling with the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Ogi K et al, 1993). PACAP receptor:PACAP peptides