cAMP degradation by Phosphodiesterases Authored: Jupe, S, 2009-04-23 15:40:54 Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes. Edited: Jupe, S, 2009-09-09 Pubmed15769620 Pubmed15798894 Reactome Database ID Release 43418553 Reactome, http://www.reactome.org ReactomeREACT_19387 Reviewed: Akkerman, JW, 2009-06-03