G-protein beta-gamma complex GPCRs that activate Gi Ligands of GPCRs that activate Gi G-protein alpha (i): GTP The Ligand:GPCR:Gi complex dissociates Authored: Jupe, S, 2010-05-18 Edited: Jupe, S, 2010-05-26 Pubmed18577758 Pubmed8736705 Reactome Database ID Release 43749454 Reactome, http://www.reactome.org ReactomeREACT_22239 Reviewed: D'Eustachio, P, 2010-05-21 The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (i) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008). Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active)