G alpha (z) inhibits adenylate cyclase Authored: Jupe, S, 2009-02-26 14:43:12 Edited: Jupe, S, 2009-09-09 G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase. Pubmed1347957 Pubmed7595566 Pubmed8327893 Reactome Database ID Release 43392064 Reactome, http://www.reactome.org ReactomeREACT_19147 Reviewed: Akkerman, JW, 2009-06-03 G-protein alpha (z):GTP:Adenylate cyclase G-protein alpha (z):GTP Adenylate cyclase (Mg2+ cofactor)