GRB2:SOS1 GRB2:SOS1:HB-EGF:p-6Y-EGFR HB-EGF:p-6Y-EGFR dimer GRB2:SOS1 binds to HBEGF:p-Y-EGFR Authored: Jassal, B, Tripathi, S, 2012-04-04 Cytoplasmic target proteins containing the SH2 domain can bind to activated EGFR. One such protein, growth factor receptor-bound protein 2 (GRB2), can bind activated EGFR with its SH2 domain whilst in complex with SOS through its SH3 domain. GRB2 can bind at either Y1068 and/or Y1086 autophosphorylation sites on the receptor (Batzer et al. 1994, Okutani et al. 1994). Edited: Jassal, B, Tripathi, S, 2012-04-04 Pubmed7518560 Pubmed7527043 Reactome Database ID Release 432179415 Reactome, http://www.reactome.org ReactomeREACT_121250 Reviewed: D'Eustachio, P, 2012-04-23