Ca(4)CaM PP2B catalytic (Fe3+, Zn2+) PP2B catalytic (Fe3+, Zn2+):Active Calmodulin Inactive catalytic PP2B is activated by the binding of calmodulin Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 PP2B (calcineurin) is a calcium-dependent, calmodulin-stimulated protein phosphatase. It comprises of two components; a catalytic subunit and a regulatory subunit which confers calcium sensitivity to the complex. PP2B is in equilibrium between active and inactive forms. Because the affinity of calmodulin for the active form is higher than for the inactive form, it stabilises PP2B. Reactome Database ID Release 43201783 Reactome, http://www.reactome.org ReactomeREACT_15299 Reviewed: Castagnoli, L, 2008-11-06 12:55:54