LATS NPHP4:LATS NPHP4 protein binds LATS proteins Authored: D'Eustachio, P, 2012-02-03 Cytosolic NPHP4 protein binds LATS proteins to form a complex. The stoiciometry of the resulting complex is unknown. When bound to NPHP4, LATS is unable to phosphorylate YAP1 and WWTR1 (TAZ) proteins, so the effect of NPHP4 binding is to antagonize this aspect of the Hippo cascade (Habbig et al. 2011). Edited: D'Eustachio, P, 2012-01-18 Pubmed21555462 Reactome Database ID Release 432059926 Reactome, http://www.reactome.org ReactomeREACT_118831 Reviewed: Sudol, M, 2012-02-03