p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:FAM123B complex SCF-beta-TrCP1 complex associated with phosphorylated beta-catenin Association of beta-catenin with the SCF-beta-TrCP1 ubiquitin ligase complex B-TrCP associates with phosphorylated beta-catenin through the B-TrCP WD40 repeat region. Currently, it is unclear whether the ubiquitin ligase binds beta-catenin after it leaves the complex. It is equally possible that it binds beta-catenin while beta-catenin is still bound to Axin. Edited: Matthews, L, 2007-04-03 12:38:03 Pubmed10023660 Pubmed9990852 Reactome Database ID Release 43195285 Reactome, http://www.reactome.org ReactomeREACT_9977 Reviewed: Pagano, M, 2007-04-27 13:02:18 SCF-beta-TrCP1 complex