LTB4 receptors BLT receptors can bind LTB4 Authored: Jassal, B, 2009-03-26 15:30:13 Edited: Jassal, B, 2009-03-26 15:30:13 Pubmed10934230 Pubmed2548477 Pubmed9177352 Reactome Database ID Release 43391941 Reactome, http://www.reactome.org ReactomeREACT_18361 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 The dihydroxy-leukotriene, leukotriene B4 (LTB4) stimulates neutrophil chemotaxis and secretion. Chemotaxis, the principal effects of LTB4 and related dihydroxy-acids on leukocytes, occurs via activation of BLT (1 and 2) receptors (Yokomizo T et al, 1997; Yokozimo T et al, 2000). BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. These receptors mediate their actions by coupling to G protein alpha q/11 subunits (McLeish KR et al, 1989) which activate a phosphatidylinositol-calcium second messenger system. LTB4 receptors:LTB4