OXE receptor:5-oxo-ETE Oxoeicosanoid receptor can bind oxoeicosanoid Authored: Jassal, B, 2009-03-26 15:30:13 Edited: Jassal, B, 2009-03-26 15:30:13 Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that are associated with cellular migration. These mediators are potent chemotaxins for eosinophils, monocytes and polymorphonuclear neutrophils. They act via the OXE receptor (Hosoi T et al, 2002), expressed principally in kidney, liver as well as in eosinophils, neutrophils, and lung macrophages. The most potent ligand is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Activation of the receptor leads to calcium mobilization and the receptor was shown to be coupled to the G alpha i subunit (Jones CE et al, 2003). Pubmed12065583 Pubmed12606753 Reactome Database ID Release 43391905 Reactome, http://www.reactome.org ReactomeREACT_18371 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22