P2RY10:LPA P2Y10 receptor can bind to LPA Authored: Jassal, B, 2009-04-14 09:13:21 Edited: Jassal, B, 2009-04-14 09:13:21 Pubmed11004484 Pubmed18466763 Reactome Database ID Release 43417842 Reactome, http://www.reactome.org ReactomeREACT_18420 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 The P2Y10 receptor is expressed during myeloid differentiation of HL60 cells (Adrian K et al, 2000) and is the first dual lysophospholipid receptor, able to bind both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) (Murakami M et al, 2008). The effects of this receptor are mediated by coupling with the G protein alpha q/11 subunit.