GPR17:UDP The UDP/CysLT (P2Y17) receptor can bind UTP Authored: Jassal, B, 2009-04-27 14:38:30 Edited: Jassal, B, 2009-04-27 14:38:30 GPR17, an orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In this example, GPR17 binds to UDP. The UDP-bound receptor couples with Gq/11 and leads to intracellular calcium increases (Ciana P et al, 2006). Pubmed16990797 Reactome Database ID Release 43418918 Reactome, http://www.reactome.org ReactomeREACT_18396 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22