5-HT1A-F/5 receptor 5-HT1 and 5A receptors can bind serotonin 5-HT1 receptors, once bound to serotonin (5-HT), act on the CNS where they induce neuronal and presynaptic inhibition and behavioural effects. In humans, there are five subtypes of the 5-HT1 receptor, designated 1A-1F (there is no 1C type) (Stam NJ et al, 1992; Hamblin MW et al, 1992; Weinshank RL et al, 1992; Zgombick JM et al, 1992; Adham N et al, 1993). 5-HT5A is expressed in human brain (Rees S et al, 1994) and has an inhibitory effect like 5-HT1 receptors. Both these subtypes mediate their actions by coupling with the G protein alpha-i/o subtype (Lin SL et al, 2002; Francken BJ et al, 1998), inhibiting adenylate cyclase activity and thus decreasing celular cAMP levels. Authored: Jassal, B, 2009-02-12 10:33:32 Edited: Jassal, B, 2009-02-12 10:33:32 Pubmed12145108 Pubmed1315531 Pubmed1330647 Pubmed1513320 Pubmed1565658 Pubmed8380639 Pubmed9865521 Reactome Database ID Release 43390929 Reactome, http://www.reactome.org ReactomeREACT_16978 Reviewed: D'Eustachio, P, 2009-03-02 09:24:35 5-HT1A-F/5 receptor:serotonin