Thyroid-stimulating hormone receptor can bind TSH Authored: Jassal, B, 2009-02-23 11:19:01 Edited: Jassal, B, 2009-02-23 11:19:01 Pubmed2558651 Pubmed8188646 Reactome Database ID Release 43391375 Reactome, http://www.reactome.org ReactomeREACT_16966 Reviewed: D'Eustachio, P, 2009-03-02 09:24:35 Thyroid-stimulating hormone (TSH, thyrotropin) is a dimeric glycoprotein synthesized and secreted by thyrotrope cells in the anterior pituitary gland. TSH regulates the endocrine function of the thyroid gland, mediating the release of the hormones thyroxine (T4) and triiodothyronine (T3). These effects are mediated by the TSH receptor (Nagayama Y et al, 1989), found primarily on thyroid follicular cells. The activated receptor couples with the G protein alpha-s subunit (Allgeier A et al ,1994) which activates adeylate cyclase and increases intracellular cAMP levels. TSH receptor:TSH Thyrotropin