Neuropeptide FF receptor Neuropeptide FF receptor:Neuropeptide FF Two NPFF receptors can bind neuropeptide FF Authored: Jassal, B, 2009-01-07 14:37:24 Edited: Jassal, B, 2009-01-07 14:37:24 Pubmed11024015 Pubmed9224703 Reactome Database ID Release 43389491 Reactome, http://www.reactome.org ReactomeREACT_17045 Reviewed: D'Eustachio, P, 2009-03-02 09:24:35 The 8 residue neuropeptide FF (NPFF, morphine-modulating peptide) (Perry SJ et al, 1997) is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors bind NPFF; NPFF1 and NPFF2 (Bonini JA et al, 2000). These receptors share the highest amino acid sequence homology with members of the orexin, NPY, and cholecystokinin families, which have been implicated in feeding. This may be a potential role for NPFF1/2. These receptors mediate the action of NPFF by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.