NPS:NPSR Neuropeptide S receptor binds neuropeptide S Authored: Jupe, S, 2009-10-23 Edited: Jupe, S, 2010-03-01 Neuropeptide S receptor (NPSR) is also called G protein-coupled receptor for asthma susceptibility (GPRA) and GPR154. NPSR is activated by neuropeptide S (NPS), a bioactive peptide that modulates stress and arousal. NPSR is thought to be Gs and Gq coupled (Gupte et al. 2004). Pubmed14757815 Pubmed15312648 Pubmed15941840 Pubmed15947423 Pubmed17613937 Reactome Database ID Release 43444620 Reactome, http://www.reactome.org ReactomeREACT_21295 Reviewed: D'Eustachio, P, 2009-12-11