Urotensin 2, 2B UTS2R:Urotensin 2, 2B Urotensin-2 receptor binds urotensin-2 and 2B Authored: Jupe, S, 2009-10-27 Edited: Jupe, S, 2010-03-01 Pubmed10499587 Pubmed14550283 Reactome Database ID Release 43445113 Reactome, http://www.reactome.org ReactomeREACT_21287 Reviewed: D'Eustachio, P, 2009-12-11 Urotensin-II (U2) is a vasoactive 'somatostatin-like' cyclic peptide originally isolated from fish spinal cords. It was found to activate GPR14 later renamed Urotensin II receptor (U2R). <br> U2 is the most potent known vasoconstrictor. A second ligand for U2R, urotensin-related peptide or Urotensin 2B, was identified as an extract from rat brains, and shown to activate rat and human U2R.