NPY family of peptides Neuropeptide Y receptors NPY peptides:NPY receptors Neuropeptide Y receptors can bind neuropeptide Y-related peptides At least four neuropeptide Y receptor subtypes each with specific affinities to neuropeptide Y peptides, serve as regulators of mucosal function, gastrointestinal motility and secretion. Four receptors have been characterized to date; NPY1R (Larhammar D et al, 1992), NPY2R (Gerald C et al, 1995), NPY4R (Bard JA et al, 1995) and NPY5R (Parker EM and Xia L, 1999).<br><br> Neuropeptide Y peptides are also implicated as mediators in the pathogenesis of many gastrointestinal disorders, including malabsorption, short gut, inflammatory bowel diseases, and forms of pancreatitis. The three peptides are neuropeptide Y (NPY) (Minth CD et al, 1984), peptide YY (PYY) (Tatemoto K et al, 1988) and pancreatic peptide (PP) (Boel E et al, 1984). <br><br>Although each peptide can bind to any of the four receptors, they each have preferred receptors. NPY binds preferentially to NPY1R, PYY to NYP2R and PP to NYP4R. Authored: Jassal, B, 2008-12-17 14:36:56 Edited: Jassal, B, 2008-12-17 14:36:56 Pubmed10461880 Pubmed1317848 Pubmed3202875 Pubmed6373251 Pubmed6589611 Pubmed7592910 Pubmed7592911 Reactome Database ID Release 43388863 Reactome, http://www.reactome.org ReactomeREACT_16924 Reviewed: D'Eustachio, P, 2009-03-02 09:24:35