Activated thrombin (factor IIa) Proteinase-activated receptors Thrombin:Proteinase-activated receptors Proteinase-activated receptors can bind thrombin Authored: Jassal, B, 2009-01-07 14:37:24 Edited: Jassal, B, 2009-01-07 14:37:24 Pubmed10079109 Pubmed8615752 Pubmed873923 Reactome Database ID Release 43389463 Reactome, http://www.reactome.org ReactomeREACT_16939 Reviewed: D'Eustachio, P, 2009-03-02 09:24:35 Thrombin (Butkowski RJ et al, 1977) plays a vital role in blood homeostasis, inflammation and wound healing. Thrombin (which cleaves bonds after arginine and lysine) converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII. Complexed with thrombomodulin it can also activate protein C. It performs these functions by binding to four proteinase-activated receptors (PAR1-4) (Kahn ML, et al, 1999; Bohm SK et al, 1996). These complexes couple to G proteins which stimulate phosphoinositide hydrolysis.