C5a receptor:C5a C5a receptor binds C5a anaphylatoxin Authored: Jassal, B, 2008-08-21 14:07:16 C5a (Fernandez HN and Hugli TE, 1978) is a protein fragment released from complement component C5. C5a is a potent anaphylatoxin, causing the release of histamine from mast cells and also being an effective leukocyte attractant. The C5a receptor (complement component 5a receptor 1, C5AR1; Cluster of Differentiation 88, CD88) (Gerard NP and Gerard C, 1991) mediates the pro-inflammatory and chemotactic actions of C5a. Edited: D'Eustachio, P, 2008-09-01 11:58:31 Pubmed1847994 Pubmed690134 Reactome Database ID Release 43375395 Reactome, http://www.reactome.org ReactomeREACT_14799 Reviewed: Bockaert, J, 2008-09-01 12:04:13