GPER:Estrogen G protein-coupled estrogen receptor 1 binds estrogen non-classically Authored: Jassal, B, 2008-08-21 14:07:16 Edited: D'Eustachio, P, 2008-09-01 11:58:31 G protein-coupled estrogen receptor 1 (GPER; CEPR; G-protein coupled receptor 30, GPR30) (Feng Y and Gregor P, 1997) has a ubiquitous tissue distribution. This orphan receptor is unrelated to nuclear estrogen receptors, but shows all the binding and signaling characteristics of a membrane estrogen receptor (mER). This suggests a role for GPCRs in nonclassical steroid hormone actions. Pubmed15539556 Pubmed9070864 Reactome Database ID Release 43374207 Reactome, http://www.reactome.org ReactomeREACT_14791 Reviewed: Bockaert, J, 2008-09-01 12:04:13