CX3C1 receptor CX3C receptor:fractalkine Receptor CX3C1 binds CX3CL1 Authored: Jassal, B, 2008-08-21 14:07:16 CX3CL1 (fractalkine) is a member of the chemokine superfamily and functions as a human leukocyte chemoattractant protein (Bazan JF et al, 1997). Unlike other human chemokines, the chemokine domain of fractalkine has three amino acids between two conserved cysteines, referred to as the CX3C motif. This molecule can exist in two forms: either membrane-anchored or as a shed 95K glycoprotein. The soluble form has potent chemoattractant activity for T-cells and monocytes, and the membrane-bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. The seven-transmembrane high-affinity receptor for fractalkine, termed CX3C1, mediates both the adhesive and migratory functions of fractalkine (Imai T et al, 1997). Edited: D'Eustachio, P, 2008-09-01 11:58:31 Pubmed9024663 Pubmed9390561 Reactome Database ID Release 43373342 Reactome, http://www.reactome.org ReactomeREACT_14810 Reviewed: Bockaert, J, 2008-09-01 12:04:13