CXCR1 ligands CXCR1:CXCR1 ligands Receptor CXCR1 binds CXCL6 and CXCL8 ligands Authored: Jassal, B, 2008-08-21 14:07:16 CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes. Edited: D'Eustachio, P, 2008-09-01 11:58:31 Pubmed1840701 Pubmed3260265 Pubmed9164944 Reactome Database ID Release 43373791 Reactome, http://www.reactome.org ReactomeREACT_14782 Reviewed: Bockaert, J, 2008-09-01 12:04:13