XC1 ligands Chemokine XC receptor 1: XC1 ligands Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta Authored: Jassal, B, 2008-08-21 14:07:16 Edited: D'Eustachio, P, 2008-09-01 11:58:31 Pubmed7602097 Pubmed7875320 Pubmed8849694 Reactome Database ID Release 43373339 Reactome, http://www.reactome.org ReactomeREACT_14858 Reviewed: Bockaert, J, 2008-09-01 12:04:13 Single C motif-1 (SCM-1; lymphotactin, CXC1) is a member of the chemokine receptor family (Yoshida T et al, 1995). CXC differs from the CC chemokines by one amino acid separating two of the four conserved cysteine residues (to give the motif CXC) whereas two adjacent cysteines denote CC. In humans, there are two highly conserved SCM-1 genes, SCYC1 and 2, which encode two SCM-1 proteins, SCM1-alpha and beta (Yoshida T et al, 1996). These proteins act as specific ligands for the CXC1 receptor. This receptor is highly expressed in placenta but lowly in spleen and thymus.