Prolysyl oxidases Lysyl oxidases Lysyl oxidase propeptides Prolysyl oxidase activation Authored: Jupe, S, 2012-04-30 EC Number: 3.4.24 Edited: Jupe, S, 2012-11-12 Lysyl oxidase (LOX) is secreted to the extracellular space in an inactive, proenzyme form (proLOX). This is proteolytically cleaved between Gly168 and Asp169 generating the mature 32-kDa enzyme. The activating proteinase is Bone morphogenetic protein 1 (BMP1), also called Procollagen C-proteinase (Cronshaw et al. 1995, Panchenko et al. 1996). Other extracellular proteases, including the BMP1 variant mammalian tolloid, tolloid-like (TLL) 1 and TLL2 proteases cleave proLOX at the correct physiological site but with lower efficiency (Uzel et al. 2001). Pubmed11313359 Pubmed7864821 Pubmed8636146 Reactome Database ID Release 432022141 Reactome, http://www.reactome.org ReactomeREACT_150462 Reviewed: Kalamajski, Sebastian, 2012-10-08 Reviewed: Raleigh, Stewart, 2012-10-08 Reviewed: Ricard-Blum, Sylvie, 2012-11-19