MMP14:TIMP2:MMP2 intermediate form MMP14:TIMP:MMP2 Autocatalytic activation of bound proMMP2 Authored: Jupe, S, 2011-09-09 Cleavage of the Asn66-Leu67 bond of MMP2 activates it sufficiently to allow autocleavage of the Asn109-Tyr110 bond (Okada et al. 1990, Strongin et al. 1993, Crabbe et al. 1994a, Atkinson et al. 1995, Sang et al. 1996). Residue numbering here refers to the UniProt canonical sequence. EC Number: 3.4.21 Edited: Jupe, S, 2012-02-21 Pubmed2269296 Pubmed7981201 Pubmed8314771 Pubmed8530478 Pubmed8804571 Reactome Database ID Release 431604368 Reactome, http://www.reactome.org ReactomeREACT_118723 Reviewed: Butler, GS, 2012-02-28 Reviewed: Overall, CM, 2012-02-28