Initial activation of proMMP2 by MMP1, 7 Authored: Jupe, S, 2011-09-09 EC Number: 3.4.21 Edited: Jupe, S, 2012-02-21 MMP2 can be activated by MMP1 (Crabbe et al. 1994a, Sang et al. 1996) and MMP7 (Crabbe et al. 1994b, Sang et al. 1996). MMP1 initially cleaves either Pro33-Ile34 or Asn66-Leu67. This is followed by autolytic cleavage at Asn109-Tyr110 (Crabbe et al. 1994a, Okada et al. 1990, Sang et al. 1996). MMP1 and MMP7 are not efficient activators of MMP2; significant physiological activation of proMMP2 is performed by the MT-MMPs MMP14 (Sato et al. 1994), MMP15 (Butler et al. 1997, Morrison et al. 2001) and MMP16 (Takino et al. 1995). Residue numbering here refers to the UniProt canonical sequence. Pubmed11584019 Pubmed2269296 Pubmed7559440 Pubmed7981201 Pubmed8015608 Pubmed8194591 Pubmed8804571 Pubmed9119036 Reactome Database ID Release 431604359 Reactome, http://www.reactome.org ReactomeREACT_118726 Reviewed: Butler, GS, 2012-02-28 Reviewed: Overall, CM, 2012-02-28