Cleaved collagen type VI fibril Collagen type VI fibril Collagen type VI degradation by MMP2,9,11 Authored: Jupe, S, 2011-07-12 EC Number: 3.4.21 Edited: Jupe, S, 2012-11-12 Pubmed14623400 Pubmed1544908 Pubmed18622425 Pubmed21935455 Pubmed6432530 Pubmed8862926 Pubmed9183676 Pubmed9334230 Reactome Database ID Release 431564112 Reactome, http://www.reactome.org ReactomeREACT_150235 Reviewed: Sorsa, Timo, 2012-10-08 Type VI collagen aggregates into distinctive microfibrils known as beaded filaments that form an independent microfibrillar network in virtually all connective tissues except for bone (von der Mark et al. 1984). It plays a role in the maintenance of tissue integrity since it participates in both cell-matrix and matrix-matrix interactions, interacting with many other ECM proteins including fibronectin (Chang et al. 1997), type IV collagen (Kuo et al. 1997), type II collagen, decorin and biglycan (Bidanset et al. 1992). Collagen type VI has been described as a connecting protein (Gelse et al. 2003). <br><br>Collagen type VI is resistant to digestion by many MMPs but is cleaved by MMP2 (Myint et al. 1996, Veidal et al. 2011), MMP9 (Veidal et al. 2011) and MMP11 (Motrescu et al. 2008).